Education

 Ph.D. -Saint Louis University School of Medicine, Saint Louis, MO 

B.Sc. -Louisiana State University, Baton Rouge, LA 

Biography

I am currently on a career path in academic medicine as a medical educator committed to cultivating a love of learning and growing the next generation of healthcare professionals. Prior to teaching in academia, I spent the earlier part of my career doing research in both academia and industry. I earned my Ph.D. in pharmacology and physiology, and I have expertise working in cellular signaling and communication. During my early research career my focus was on understanding red blood cell communication in the microcirculation with an end goal of improving blood circulation in patients with diabetes. I then transitioned to the cardiovascular system where my focus was to understand vascular smooth muscle cell proliferation as it related to prevention of stent restenosis in patients with atherosclerosis. The latter part of my research career was in microcirculation and focused on understanding cellular signaling in lymphatic endothelial cells, where endothelial cell permeability contributes to tissue edema. 

My teaching career began after my time as a research scientist. I am experienced in designing and implementing engaging and evidence-based curricula for medical students, physician assistants and graduate students. I have proven ability to effectively teach complex medical concepts and mentor students in their professional development. I have mentored and advised medical, doctoral, and undergraduate students in the laboratory as well as in academia. I am actively involved in professional development activities, including attending conferences, workshops, and learning from other medical educators. 

As a medical educator for the past several years my teaching philosophy has continued to evolve as education, technology and students evolve. Continuous refinement of the teaching process, assessment and evaluation are integral for the learning process. There is a Latin proverb, “By learning you will teach; by teaching you will learn.” I am dedicated to innovation and excellence in my teaching to ensure that I am reaching the next generation of health science professionals. 

Publications

Sprague RS, Bowles EA, Hanson MS, DuFaux EA, Sridharan M, Adderley S, Ellsworth ML, Stephenson AH. Prostacyclin analogs stimulate receptor-mediated cAMP synthesis and ATP release from rabbit and human erythrocytes. Microcirculation. 2008:461-71. 

Hanson MS, Stephenson AH, Bowles EA, Sridharan M, Adderley S, Sprague RS. Phosphodiesterase 3 is present in rabbit and human erythrocytes and its inhibition potentiates iloprost-induced increases in cAMP. Am J Physiol Heart Circ Physiol. 2008:H786-93. 

Adderley SP, Dufaux EA, Sridharan M, Bowles EA, Hanson MS, Stephenson AH, Ellsworth ML, Sprague RS. Iloprost- and isoproterenol-induced increases in cAMP are regulated by different phosphodiesterases in erythrocytes of both rabbits and humans. Am J Physiol Heart Circ Physiol. 2009:H1617-24. 

Sprague RS, Hanson MS, Achilleus D, Bowles EA, Stephenson AH, Sridharan M, Adderley S, Procknow J, Ellsworth ML. Rabbit erythrocytes release ATP and dilate skeletal muscle arterioles in the presence of reduced oxygen tension. Pharmacol Rep. 2009:183-90. 

Hanson MS, Ellsworth ML, Achilleus D, Stephenson AH, Bowles EA, Sridharan M, Adderley S, Sprague RS. Insulin inhibits low oxygen-induced ATP release from human erythrocytes: implication for vascular control. Microcirculation. 2009:424-33. 

Adderley SP, Sprague RS, Stephenson AH, Hanson MS. Regulation of cAMP by phosphodiesterases in erythrocytes. Pharmacol Rep. 2010:475-82. Review. 

Adderley SP, Sridharan M, Bowles EA, Stephenson AH, Ellsworth ML, Sprague RS. Protein kinases A and C regulate receptor-mediated increases in cAMP in rabbit erythrocytes. Am J Physiol Heart Circ Physiol. 2010:H587- 93. 

Sridharan M, Sprague RS, Adderley SP, Bowles EA, Ellsworth ML, Stephenson AH. Diamide decreases deformability of rabbit erythrocytes and attenuates low oxygen tension-induced ATP release. Exp Biol Med (Maywood). 2010:1142-8. 

Sridharan M, Adderley SP, Bowles EA, Egan TM, Stephenson AH, Ellsworth ML, Sprague RS. Pannexin 1 is the conduit for low oxygen tension-induced ATP release from human erythrocytes. Am J Physiol Heart Circ Physiol. 2010:H1146-52. 

Adderley SP, Thuet KM, Sridharan M, Bowles EA, Stephenson AH, Ellsworth ML, Sprague RS. Identification of cytosolic phosphodiesterases in the erythrocyte: a possible role for PDE5. Med Sci Monit. 2011:CR241-7. 

Adderley SP, Sridharan M, Bowles EA, Stephenson AH, Sprague RS, Ellsworth ML. Inhibition of ATP release from erythrocytes: a role for EPACs and PKC. Microcirculation. 2011:128-35. 

Adderley SP, Joshi CN, Martin DN and Tulis DA. Phosphodiesterases regulate BAY41- 2272-induced VASP phosphorylation in vascular smooth muscle cells. Front. Pharmacol.2012. 3:10. 

Adderley, Shaquria, Chintamani N. Joshi, Danielle N. Martin, Shayna Mooney and David A. Tulis (2012). Multiple kinases regulate vascular growth. Dr. Gabriela Da Silva Xavier (Ed.), ISBN: 978-953-51-0633-3, InTech. 

Adderley, SP, Xun E. Zhang and Jerome W. Breslin. Involvement of the H1 histamine receptor and p38 MAP kinase in histamine-induced endothelial barrier dysfunction. Microcirculation, 2015. 

Adderley, SP, Danielle N. Martin and David A. Tulis. Exchange Protein Activated by cAMP (EPAC) Controls Migration of Vascular Smooth Muscle Cells in Concentration- and Time-dependent Manner. Archives of 

Physiology, 2015. 

Adderley SP, Lawrence C, Madonia E, Olubadewo JO, Breslin JW. Histamine activates p38 MAP kinase to disrupt local lamellipodia and endothelial barrier integrity. AJP; Cell Physiology, 2015. 

Zhang XE, Adderley SP, Breslin JW. Activation of RhoA, but not Rac1, mediates early stages of S1P-induced endothelial barrier enhancement. PLOS ONE. 2016. 

Andrew W. Holt, Danielle N. Martin, Patti Shaver, Shaquria P. Adderley, Joshua D. Stone, Chintamani N. Joshi, Jake T. Francisco, Robert M. Lust, Brian M. Shewchuk, & David A. Tulis. Soluble guanylyl cyclase-activated cyclic GMP-dependent protein kinase inhibits arterial smooth muscle cell migration independent of VASP-Serine 239 phosphorylation. Cellular Signalling, 2016. 

Lymphatic Vessel Network Structure and Physiology Jerome W. Breslin, Ying Yang, Joshua P. Scallan, Richard S. Sweat, Shaquria P. Adderley, and W. Lee Murfee, Comprehensive Physiology, 2018. 

Madison D. Williams, Michael T. Bullock, Sean C. Johnson, Nathan A. Holland, Danielle M. Vuncannon, Joani Zary Oswald, Shaquria P. Adderley, David Anthony Tulis. Protease-activated receptor 2 controls vascular smooth muscle cell proliferation in cyclic AMP-dependent protein kinase/mitogen-activated protein kinase kinase 1/2-dependent manner. Journal of Vascular Research, 2023.